IV. Operational Material Safety Data Sheet
UMass Boston employs a comprehensive hazard management information system as part of the Laboratory Chemical Hygiene Program. Under this program, manufacturer's Material Safety Data Sheets are replaced by Operational Material Safety Data Sheets (Op MSDSs) which contain additional information and more quantitative presentation of health risk. EH&S has prepared one-page Op MSDSs for each chemical at the facility. A complete set of these Op MSDSs are present in each laboratory at UMB. It is essential that you use this information in your design of safe operating procedures.. One of these should be available for every chemical present in your laboratory. Consult these to determine the nature and degree of hazard posed by the procedure which you are designing. The information on these sheets is organized as:
* Name and Chemical Abstract Series #
* The Hazard Index for the chemical
* NFPA Hazard Codes
* Limit Values proposed by OSHA, NIOSH or the ACGIH
* Toxicity Data
* Identification and quantification of the relative potency of the hazard for:
o Inhalation Hazards
Neurotoxins
Reproductive Toxins and Teratogens
Carcinogens
* Particular Significant or Unusual Effects of the Chemical
* Acute Health Hazards and Symptoms of Exposure
* Chronic Health Hazards
* Physical Hazards
* Adverse Chemical Reactions
* Physical Appearance and Characteristics.
* Data Relevant to Safe Storage
* Chemical Reactivity Information
* Appropriate Fire Extinguisher
* Unusual Toxic Emissions when Burned
SAMPLE OPERATIONAL MATERIAL SAFETY DATA SHEET
1,1-DIMETHYLHYDRAZINE CAS # 57147
| A Special Carcinogen | D Inhalation Hazard | G Eye Damage | J Suspect Carcinogen |
| B Human Terato\Repro Haz | E Dermal Hazard | H STEL | K Suspect Terato\Repro Haz |
| C Highly Toxic | F Corrosive | I Neurotoxin | L Sensitizers |
HAZARD INDEX A . . D E F G . I . K .
NFPA HAZARD CODES (H,F,R,O) 3 3 1
SPECIAL CARCINOGEN - DESIGNATED AREA MAY BE REQUIRED - CHRONIC TOXICITY TD50 5 ++ 1.21 mg/Kg
ACUTE TOXICTY 3.9 122 mg/Kg
INHALATION HAZARD- RISK INDEX 4.2
OSHA PERMISSIBLE EXPOSURE LIMIT .5 PPM
WARNING: UNSYMMETRICAL DIMETHYLHYDRAZINE CAN CAUSE CONVULSIONS RESULTING IN DEATH, PULMONARY EDEMA, CNS STIMULATION AND HEMOLYTIC ANEMIA.
ACUTE EFFECTS
MAY BE FATAL IF INHALED, SWALLOWED, OR ABSORBED THROUGH SKIN.
MATERIAL IS EXTREMELY DESTRUCTIVE TO TISSUE OF THE MUCOUS MEMBRANES AND UPPER RESPIRATORY TRACT, EYES AND SKIN.
INHALATION MAY BE FATAL AS A RESULT OF SPASM, INFLAMMATION AND EDEMA OF THE LARYNX AND BRONCHI, CHEMICAL PNEUMONITIS AND PULMONARY EDEMA.
SYMPTOMS OF EXPOSURE MAY INCLUDE BURNING SENSATION, COUGHING, WHEEZING, LARYNGITIS, SHORTNESS OF BREATH, HEADACHE, NAUSEA AND VOMITING.
CHRONIC EFFECTS
CARCINOGEN.
MAY ALTER GENETIC MATERIAL.
EXPOSURE CAN CAUSE:
DAMAGE TO THE LIVER
DAMAGE TO THE KIDNEYS
BLOOD EFFECTS
GASTROINTESTINAL DISTURBANCES
PHYSICAL CHARACTERISTICS
MAY IGNITE SPONTANEOUSLY WHEN SPREAD ON A LARGE SURFACE. IGNITES SPONTANEOUSLY IN THE PRESENCE OF OXIDANTS SUCH AS HYDROGEN PEROXIDE AND FUMING NITRIC ACID. IGNITES WITH SPARKING WHEN MIXED WITH NITRIC OXIDE.
PHYSICAL STATE
COLORLESS TO YELLOW LIQUID
FLAMMABLE
EXPLOSIVE
VAPOR PRESSURE 103.0000 mm Hg @ 20 C
FLASH POINT 34 F
SEGREGATION: SHELF # 1
STORAGE GROUP(S):
a - ORGANIC BASE/FLAMMABLE/TOXIC
b - PYROPHORIC/WATER REACTIVE
l - FLAMMABLE/COMBUSIBLE SOLVENT
WASTE CHARACTERISTIC HAZARD:
IGNITABLE REACTIVE TOXIC CORROSIVE
INCOMPATIBILITIES:
OXIDIZING AGENTS
COPPER, COPPER ALLOYS
BRASS
IRON AND IRON SALTS
FIRE EXTINGUISHER: WATER SPRAY. CARBON DIOXIDE, DRY CHEMICAL POWDER OR APPROPRIATE FOAM.
EXPLANATION OF INFORMATION CONTAINED IN THE OPERATIONAL MSDS
NFPA HAZARD INDEX Where assigned, the National Fire Protection Association index is presented. This code contains a numerical designation of severity (from 0, lowest to 4, highest) in the categories Health, Flammability, Reactivity, and a letter designator in the category of Other indicating oxidizing activity (OX), violent reactivity with water (W), or compressed gas (G).
NFPA codes exist only for a selected list of chemicals in widespread use in manufacturing. While especially useful in identifying potential fire or explosion threat, the absence of a code should not be taken as the absence of hazard.
SELECT CARCINOGEN, TOXIN, NEUROTOXIN, OR REPRODUCTIVE TOXIN. If the chemical falls into one of the especially toxic categories (Carcinogenicity, Nonspecific Systemic Toxicity, Neurotoxicity, or Reproductive Toxicity), this information is next presented. Where quantitative or indexed data is available, this too is presented.
REGULATORY LIMIT VALUES. If exposure limits have been set for the chemical they will be presented here. Note that particular attention should be paid to Short Term Exposure Limits (STELs) or Ceiling Limit Values (CEILs) which indicate significant hazard exists even for brief exposure.
TOXICITY. Where available, data will be presented on chronic and acute toxicity, as well as indexed values for inhalation, neurotoxic, and teratogenic or reproductive risk potential. Note that for any particular chemical risk may be limited to only one of these categories.
SPECIAL WARNINGS. In some cases, the manufacturer has identified specific circumstances which create unusual hazard, or especially significant or unusual toxic effects which are presented here.
ACUTE HEALTH EFFECTS. This entry comprises a list of the known toxic outcomes involving short-term exposure to high concentrations of a chemical. These types of exposures are typically sudden and severe and may lead to irritation, illness or death.
CHRONIC HEALTH EFFECTS. This entry comprises a list of known toxic outcomes of continuous or long-term exposure to the chemical.
PHYSICAL CHARACTERISTICS. If the manufacturer has identified specific or unusual conditions/reactions pertaining to this chemical, they will be presented here. Following this, information is presented on the following characteristic where available:
APPEARANCE. This entry describes the typical appearance of the product as supplied by the manufacturer. Note that if the material is listed as a solid, but exists in the spill as a liquid, the presence of an unknown solvent must be inferred.
FLAMMABILITY. Based on flash point and reactivity, where applicable the chemical will be identified as flammable, combustible, or explosive.
VAPOR PRESSURE. The vapor pressure is the partial pressure (in mmHg) exerted by the gas-phase of a liquid in the head space of an enclosing container at 20°C at normal atmospheric pressure (760 mmHg). As such, it is an indicator of the tendency of the chemical to 'off-gas'. Solids and 'oily' liquids typically have values less than 5 mmHg. Water has a vapor pressure of approximately 12 mmHg, and the range for many alcohols is 12 to 50 mmHg. Aromatic Hydrocarbon solvents typically fall in the range of 5-25 mmHg, and Aliphatic Hydrocarbons 100-500 mmHg (Chloroform - 160 mmHg; Ethyl Ether - 442 mmHg). Vapor Pressures greater than 760 mmHg define a gas at normal temperature and pressure (Chlorine - 4800 mmHg).
FLASH POINT. Flash point is the temperature (in °Fahrenheit) at which a flammable liquid can release enough vapor in air to reach the LEL (lower explosive limit) or LFL (lower flammable limit). The LEL is the minimum concentration (usually described in %) of a flammable vapor or gas in air that will support combustion if an ignition source is present. It is not the ignition temperature. This is a critical value in spill control. A value near or below room temperature indicates that the material may form a flammable range of vapor at a distance from the spilled source which may 'flash back' and ignite the source. It is also critical with regard to storage. A chemical with a flash point at or below that of the laboratory refrigerator (approx. 40 °Fahrenheit) is capable of forming an ignitable atmosphere in the sealed box. Such a chemical must not be stored in a conventional refrigerator where potential ignition sources (lights, compressor motor) are located. Store instead in a UP listed flammable refrigerator, or tightly stoppered on the bench.
PEROXIDE OR PEROXIDE FORMER. This information indicates that the chemical is or may form unstable peroxides capable of self-detonating or sensitive to small inputs of energy.
WATER REACTIVE. This information indicates that the chemical reacts violently with water generating heat or fire, or producing toxic or flammable gas.
INCOMPATIBILITIES. This category presents a list of chemicals or characteristics of chemicals known to produce violent thermal or toxic reactions on mixing with the chemical.
FIRE EXTINGUISHER. The most appropriate fire extinguisher type is listed here.
CHEMICAL STORAGE GROUPS- GUIDELINES
Storage group guidelines are used for:
- storing solids, liquids and gases;
- grouping hazardous chemicals in the same secondary containment tray, including laboratory waste; and
- determining the appropriate re-use of empty chemical containers
Never store chemicals from different storage groups in the same secondary container.
STORAGE GROUP CHEMICALS
A Compatible Organic Bases, Flammables and Toxics
B Pyrophoric and Water Reactive Materials
C Compatible Inorganic Bases, Oxidizers and Toxics
D Compatible Organic Acids, Flammables and Toxics
E Compatible Oxidizers, Organic Peroxides and Acids
F Inorganic Acids not including Oxidizing or Organic Acids
G Non-Reactive Materials and Non-Hazardous Materials
H Flammable or Pyrophoric Compressed Gases
I Compatible Corrosive and Oxidizing Gases and Inert Gases
J Poison Compressed Gases
K Explosive or other unstable material
L Solvents, Flammables and Combustible Materials
X Needs secondary containment separate from ALL groups and from each other individually
Storage Groups that can be stored on the same shelf, or within the same storage cabinet, if each group is segregated by secondary containment:
SHELF STORAGE GROUP
1 A, B, D, G, L
2 C, E, F, G
3 X
