This course will systematically investigate cell communication mechanisms, with an emphasis on developmental examples of cell signaling. General properties of signaling cascades will be discussed, followed by specific examples of conserved signaling pathways, such as Notch, Wnt, Hedgehog, TGF/BMP, JAK/STAT, nuclear receptors; and receptor tyrosine kinases (RTKs). Normal and aberrant receptor signaling will be examined using experimental evidence obtained in model genetic organisms. Implications of disrupting cell communication pathways in human disease will be discussed. The course will emphasize readings from the current literature. Upon completion of this course, students will have a solid understanding of the molecular mechanisms and control principles of cellular communication in normal and pathological conditions.
Pre Requisites: Pre-requisite = Graduate degree student in Biology or permission.