UMass Boston News

Dissertation Defense: Asharani Kadam, PhD Candidate, Green Chemistry Track, Chemistry Department

Event Date: March 04, 2014 - 11 a.m.
Event Type: Open to public
Location: Science Center, Chemistry Conference Room (Science S01-0089)


University of Massachusetts Boston

Department of Chemistry

Dissertation Defense

Green Techniques to Improve Grignard Reactions and Synthesize Heterocyclic Molecules

Presented by Asharani Kadam

for the PhD in Chemistry, Green Chemistry Track

Advisor: Professor Wei Zhang

Tuesday, March 4, 2014 12 - 1 PM

Chemistry Conference Room | Science S01-0089

Green chemistry integrates environmentally safe and sustainable technologies for chemical research and production. Many classical synthetic methods, even with widespread applicability and significance, have various drawbacks due to use of harsh conditions, harmful reagents, long reaction times and generation of large amounts of waste. The goal of this thesis is to apply several of the twelve principles of green chemistry to modify traditional processes or develop new processes for chemical synthesis. This thesis covers green chemistry related research projects including: 1) The development of new solvents for the Grignard reaction. The reactions of selected substrates in seven solvents were evaluated. The objective is to encourage Grignard reagent suppliers to provide organometallic reagents in greener solvents. 2) The development of an efficient method to synthesize tetrasubstituted furans. A fluorous multi-step synthesis is combined with a microwave-reaction and fluorous solid-phase extraction (F-SPE) to improve reaction and separation efficiency. 3) The development of atom- and step-economic synthesis of the biaryl substituted furocoumarins, furoquinolones and furopyrimidines by microwave-assisted sequential multi-component and the Suzuki coupling reactions. 4) The development of a new method for the synthesis of ether linkage by Pd-catalyzed coupling reaction of fluorous sulfonates. Additionally, some complex compounds were also synthesized for biological screening and quantitative structure-activity relationship (QSAR) studies.

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