Dissertation Defense: Asharani Kadam, PhD Candidate, Green Chemistry Track, Chemistry Department
University of Massachusetts Boston
Department of Chemistry
Green Techniques to Improve Grignard Reactions and Synthesize Heterocyclic Molecules
Presented by Asharani Kadam
for the PhD in Chemistry, Green Chemistry Track
Advisor: Professor Wei Zhang
Tuesday, March 4, 2014 | 12 - 1 PM
Chemistry Conference Room | Science S01-0089
Green chemistry integrates environmentally safe and sustainable technologies for chemical research and production. Many classical synthetic methods, even with widespread applicability and significance, have various drawbacks due to use of harsh conditions, harmful reagents, long reaction times and generation of large amounts of waste. The goal of this thesis is to apply several of the twelve principles of green chemistry to modify traditional processes or develop new processes for chemical synthesis. This thesis covers green chemistry related research projects including: 1) The development of new solvents for the Grignard reaction. The reactions of selected substrates in seven solvents were evaluated. The objective is to encourage Grignard reagent suppliers to provide organometallic reagents in greener solvents. 2) The development of an efficient method to synthesize tetrasubstituted furans. A fluorous multi-step synthesis is combined with a microwave-reaction and fluorous solid-phase extraction (F-SPE) to improve reaction and separation efficiency. 3) The development of atom- and step-economic synthesis of the biaryl substituted furocoumarins, furoquinolones and furopyrimidines by microwave-assisted sequential multi-component and the Suzuki coupling reactions. 4) The development of a new method for the synthesis of ether linkage by Pd-catalyzed coupling reaction of fluorous sulfonates. Additionally, some complex compounds were also synthesized for biological screening and quantitative structure-activity relationship (QSAR) studies.
For disability-related accommodations, including dietary accommodations, please visit www.ada.umb.edu two weeks prior to the event.