Faculty Candidate Seminar: Monika Raj, Postdoctoral Fellow, Arora Laboratory, New York University
University of Massachusetts Boston
Department of Chemistry
Faculty Candidate Seminar
Aldehyde Capture Ligation: A Chemoselective Approach to Peptides and Bioconjugates
Dr. Monika Raj
New York University
New York, NY
Wednesday, February 26, 2014 | 11:00 AM
Chemistry Conference Room (Science S01-0089)
Chemoselective reactions for amide bond formation have transformed the ability to access synthetic proteins and other bioconjugates through ligation of fragments. In these ligations, amide bond formation is accelerated by transient enforcement of an intramolecular reaction between the carboxyl and the amine termini of two fragments. Building on this principle, this talk will describe an auxiliary-based approach called “aldehyde capture ligation (ACL)” that parlays the chemoselective reactivity of aldehydes and amines to enforce amide bond formation between unprotected peptide segments.
For disability-related accommodations, including dietary accommodations, please visit www.ada.umb.edu two weeks prior to the event.