Faculty Candidate Seminar: Monika Raj, Postdoctoral Fellow, Arora Laboratory, New York University

Event Date: February 26, 2014 - 10 a.m.
Event Type: Open to public
Location: Science Center, Chemistry Conference Room (Science S01-0089)

University of Massachusetts Boston

Department of Chemistry

Faculty Candidate Seminar

Aldehyde Capture Ligation: A Chemoselective Approach to Peptides and Bioconjugates

Dr. Monika Raj

Postdoctoral Fellow

Arora Laboratory

New York University

New York, NY

Wednesday, February 26, 2014 | 11:00 AM

Chemistry Conference Room (Science S01-0089)

Chemoselective reactions for amide bond formation have transformed the ability to access synthetic proteins and other bioconjugates through ligation of fragments. In these ligations, amide bond formation is accelerated by transient enforcement of an intramolecular reaction between the carboxyl and the amine termini of two fragments. Building on this principle, this talk will describe an auxiliary-based approach called “aldehyde capture ligation (ACL)” that parlays the chemoselective reactivity of aldehydes and amines to enforce amide bond formation between unprotected peptide segments.

For disability-related accommodations, including dietary accommodations, please visit www.ada.umb.edu two weeks prior to the event.