UMass Boston

Mechanisms of Mutagenesis and Genomic Instability in Human Cells

ScD, Harvard University, Radiation Biology (1982)
MS, Harvard University, Radiation Biology (1979)
AB, Boston University, Biology (1975)

• Rebecca N. Allen, Linda E. Ritter, and Andrew J. Grosovsky, Generation of Persistent Genomic Instability by Stable Transfection with Alpha or Classical Satellite DNA. DNA Repair, In revision following review (2008)
• Efrem A. H. Neuwirth, and Andrew J. Grosovsky. Interchromosomal Crossing-over in Human Cells is Associated with Long Gene Conversion Tracts. Mol. Cell Biol 27:5261-74 (2007)
• Stephen R. Moore, David Papworth, and Andrew J. Grosovsky. Non-Random Distribution of Instability-Associated Chromosomal Rearrangement Breakpoints in Human Lymphoblastoid Cells. Mutation Research 2006 600:113-24 (2006)
• Moore, S.R., Ritter, L.E., Gibbons, C.F., Grosovsky, A.J. Spontaneous and radiation-induced genomic instability in human cell lines differing in cellular TP35 status. Radiation Research 164:357-68. (2005)
• Pongsaensook, P., Ritter, L.E., Parks, K.K., and Grosovsky, A.J. Cis-acting transmission of genomic instability. Mutation Research 568:49-68. (2004)
• Quintana, PJ; Neuwirth, EA; Grosovsky, AJ. Interchromosomal gene conversion at an endogenous human cell locus. Genetics 158:757-67 (2001)
• Meng, Q., Grosovsky, A.J., Shi, X., and Walker, V.E., Mutagenicity and loss of heterozygosity at the APRT locus in human lymphoblastoid cells exposed to 3’-azido-3’-deoxythymidine. Mutagenesis 15: 405-410 (2000)
• Giver, C.R. and Grosovsky, A.J., Radiation Specific Patterns of Loss of Heterozygosity on Chromosome 17q. Mutation Research 450: 201-209 (2000)
• Sasaki, J.C., Arey, J., Eastmond, D.A., Parks, K.K., Phousongphouang, P., and Grosovsky, A.J. Evidence for oxidative metabolism in the genotoxicity of the atmospheric reaction product 2-nitronaphthalene in human lymphoblastoid cell lines, Mutation Research 445: 113-125. (1999)
• Smith, H.M., and Grosovsky, A.J., PolyADP-Ribose Mediated Regulation of Complexed p53 and Topoisomerase I Following Ionizing Radiation, Carcinogenesis 20: 1439-1444. (1999)
• Grosovsky, AJ. Radiation-induced mutations in unirradiated DNA. Proc. Nat’l. Acad. Sci., USA 96:5346-5347 (1999)
• Fry, R.J.M., Grosovsky, A.J.,. Hanawalt, P.C, Jostes, R.F., Little, J.B., Morgan, W.F., Oleinick, N.L., Ullrich, R.L., The Impact of Biology on Risk Assessment – Workshop of the National Research Council and the Board of Radiation Effects Research, Radiation Research 150:695 (1998)
• Smith, L.E., Parks, K., Hasegawa, L., Eastmond, D.A. and Grosovsky, A.J. Breakage of Pericentromeric Heterochromatin is a Potent Inducer of Chromosomal Instability. Mutagenesis 13:435-443 (1998)
• Dobo, K.L., Eastmond, D.A., and A.J. Grosovsky, Sequence Specific Mutations Induced by N-Nitrosodimethylamine at Two Marker Loci in Metabolically Competent Human Lymphoblastoid Cells. Carcinogenesis 19:755-764 (1998)
• Dobo, K.L., Eastmond, D.A., and A.J. Grosovsky, The Influence of Cellular Apoptotic Capacity on N-Nitrosodimethylamine-Induced Loss of Heterozygosity Mutations in Human Cells., Carcinogenesis, 18:1701-1707 (1997)
• Sasaki, J.C., Arey, J., Eastmond, D.A., Parks, K.K., and Grosovsky, A.J. Genotoxicity Induced in Human Lymphoblasts by Atmospheric Reaction Products of Naphthalene and Phenanthrene. Mutation Res.,393:23-35 (1997)
• Giver, C.R., and A. J. Grosovsky, Single and Coincident Intragenic Mutations Attributable to Gene Conversion in a Human Cell Line, Genetics,146: 1429-1439 (1997)
• Pongsaensook, P., Smith, L.E., and Grosovsky, A.J. Isolation of an APRT Heterozygote from TK6 Human Lymphoblasts: Predominance of Multi-Locus Loss of Heterozygosity among Spontaneous APRT- Mutants. Mutation Res. 377: 27-36 (1997)
• Grosovsky, A., Parks, K., Giver, C., and Nelson, S. Clonal Analysis of Delayed Karyotypic Abnormalities and Gene Mutations in Radiation Induced Genetic Instability. Molecular and Cellular Biology 16:6252-6262 (1996)
• Nelson, S., Parks, K., Grosovsky, A. Ionizing Radiation Signature Mutations in Human Cell Mutants Induced by Low Dose Exposures. Mutagenesis, 11: 275-279 (1996)
• Giver, C. R., Nelson, S. L., Pongsaensook, P., and A. J. Grosovsky, Mutational Spectra of Spontaneous and X-Ray Induced TK- Human Cell Mutants, Carcinogenesis 16: 267-275 (1995)
• Dobo, K.L., Eastmond, D.A., Rumbos, H.S., Giver, C.R., and A.J. Grosovsky,Extensive Loss of Heterozygosity Accounts for Differential Mutation Rate on Chromosome 17q in Human Lymphoblasts., Mutagenesis 10: 53-58 (1995)
• Nelson, S.L., Jones, I.M., Fuscoe, J., and A. J. Grosovsky, Mapping the Endpoints of Large Deletions Affecting the hprt Locus in Human Peripheral Blood Cells and Cell Lines., Radiation Research 141: 2-10, (1995)
• Nelson, S.L, Giver, C.R. and Grosovsky, A.J. Spectrum of X-Ray induced Mutations in the Human hprt Gene, Carcinogenesis 15: 495-502 (1994)
• Grosovsky, A.J., Walter, B. W. and C.R. Giver, DNA Sequence Specificity of Mutations at the Human Thymidine Kinase Locus, Mutation Res. 289: 231-243 (1993)
• Giver, C.R., Nelson, S. L., and A. J. Grosovsky,Spectrum of Spontaneous HPRT- Mutations in TK6 Human Lymphoblasts, Env. Molec. Mutagenesis 22: 138-146 (1993)
• Smith, L. E., and Grosovsky, A. J., Evidence for High Frequency Allele Loss at the aprt Locus in TK6 Human Lymphoblasts, Mutation Res. 289: 245-254 (1993)
• Smith, L.E., and Grosovsky, A.J., Genetic Instability on Chromosome 16 in a Human Lymphoblastoid Cell Line, Somatic Cell Molec. Genet. 19: 515-527 (1993)
• Ward, M. A., Yu, M., Glickman, B. W. and A. J. Grosovsky. Loss of heterozygosity in mammalian cell mutagenesis: Molecular analysis of spontaneous mutations at the aprt locus in CHO cells. Carcinogenesis 11:1485-1490. (1990)
• Grosovsky, A.J., deBoer, J.G., Drobetsky, E.A., and B.W. Glickman, Base substitu­tions, frameshifts and small deletions comprise ionizing radiation induced point mutations in mammalian cells, Proc. Natl. Acad. Sci., U.S.A., 85: 185-188 (1988)
• deJong,P.J., Grosovsky,A.J., and B.W. Glickman, Spectrum of spontaneous mutation at the aprt locus of CHO cells Proc. Natl. Acad. Sci., U.S.A., 85: 3499-3503 (1988)
• Grosovsky, A.J., Drobetsky, E.A., deJong, P.J., and B.W. Glickman, Southern analysis of gamma ray induced alterations in APRT- ham­ster cell mutants, Genetics, 113: 405-415, (1986)
• Grosovsky, A.J. and J.B.Little, Evidence for linear induction of mutations in human cells by X-ray exposures of 1-10 rads, Proc. Natl. Acad. Sci. U.S.A., 82: 2092-2095, (1985)

• Vice Provost, Undergraduate Education, University of California, Riverside (2004-2007).
• Assistant, Associate, Full Professor, Department of Cell Biology and Neuroscience, University of California, Riverside (1989-2007).
• Vice Provost, University of California, Riverside (2004-2007).
• Professor, University of California, Riverside (1999-2007).
• Associate Professor, University of California, Riverside (1995-1999).
• Assistant Professor, University of California, Riverside (1989-1995).
• Assistant Professor, York University (1986-1988).
• Research Associate, York University (1984-1986).
• Research Fellow, Harvard School of Public Health (1982-1984).
• Research Assistant, Harvard Medical School (1975-1977).