GRAD > BIOL > 666
This course provides a background in principles of toxicology in mammalian systems. It is an alternative to Environmental Toxicology, EEOS 635, as a core requirement for the Molecular, Cellular, and Organismal Biology doctoral track. Coverage includes: basic concepts of poisons and their commonalities with drugs and hormones ;toxicant exposure routes, uptake, sites and mechanisms of action, storage, metabolism, activation, and clearance; toxicant roles in carcinogenesis, development, endocrine, and reproductive functions; roles of diet, lifestyle, and concurrent exposures; methods of toxicant evaluation emphasizing multi-generation and high-throughput testing; and environmental and medical implications of toxicant/toxin expores on individual health. Students taking this course should have already completed general chemistry and organic chemistry, general biology and one advanced course in cell biology, biochemistry, or physiology.