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Publications
Flavoprotein monooxygenases
Gonzalez R, Soule J, Phan N, Wicht DK, Dowling DP. Structural, biophysical, and biochemical insights into C-S bond cleavage by dimethylsulfone monooxygenase. Proc Natl Acad Sci U S A. 2024 Nov 19;121(47):e2401858121. PubMed Central PMCID: PMC11588060.
Liew J, Wicht D, Gonzalez R, Dowling D, Ellis H. Current understanding of enzyme structure and function in bacterial two-component flavin-dependent desulfonases: Cleaving C–S bonds of organosulfur compounds. Archives of Biochemistry and Biophysics. 2024 August; 758:110048-. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0003986124001693 DOI: 10.1016/j.abb.2024.110048
Liew JJM, El Saudi IM, Nguyen SV, Wicht DK, Dowling DP. Structures of the alkanesulfonate monooxygenase MsuD provide insight into C-S bond cleavage, substrate scope, and an unexpected role for the tetramer. J Biol Chem. 2021 Jul;297(1):100823. PubMed Central PMCID: PMC8234197.
Soule J, Gnann AD, Gonzalez R, Parker MJ, McKenna KC, Nguyen SV, Phan NT, Wicht DK, Dowling DP. Structure and function of the two-component flavin-dependent methanesulfinate monooxygenase within bacterial sulfur assimilation. Biochem Biophys Res Commun. 2020 Jan 29;522(1):107-112. PubMed PMID: 31753487.
Pyrimidine base hypermodification
Lee YJ, Dai N, Müller SI, Guan C, Parker MJ, Fraser ME, Walsh SE, Sridar J, Mulholland A, Nayak K, Sun Z, Lin YC, Comb DG, Marks K, Gonzalez R, Dowling DP, Bandarian V, Saleh L, Corrêa IR, Weigele PR. Pathways of thymidine hypermodification. Nucleic Acids Res. 2022 Apr 8;50(6):3001-3017. PubMed Central PMCID: PMC8989533.
Potential targets for cancer therapeutics
Webb J, Liew, JJM, Gnann AD, Ilkhani K, Patterson M, Paul S, Forés M, Jiménez G, Veraksa A, Dowling DP. Molecular basis of DNA recognition by the HMG-box-C1 module of capicua. Structure. 2025 Sep 24; doi: 10.1016/j.str.2025.08.018.
Enzymes in natural product biosynthesis
Gnann AD, Marincin K, Frueh DP, Dowling DP. Dynamics and mechanistic interpretations of nonribosomal peptide synthetase cyclization domains. Curr Opin Chem Biol. 2023 Feb;72:102228. PubMed PMID: 36402006; NIHMSID: NIHMS1836243.
Gnann AD, Xia Y, Soule J, Barthélemy C, Mawani JS, Musoke SN, Castellano BM, Brignole EJ, Frueh DP, Dowling DP. High-resolution structures of a siderophore-producing cyclization domain from Yersinia pestis offer a refined proposal of substrate binding. J Biol Chem. 2022 Oct;298(10):102454. PubMed Central PMCID: PMC9547227.
Mishra SH, Kancherla AK, Marincin KA, Bouvignies G, Nerli S, Sgourakis N, Dowling DP, Frueh DP. Global protein dynamics as communication sensors in peptide synthetase domains. Sci Adv. 2022 Jul 15;8(28):eabn6549. PubMed Central PMCID: PMC9286511.
Dowling DP, Kung Y, Croft AK, Taghizadeh K, Kelly WL, Walsh CT, Drennan CL. Structural elements of an NRPS cyclization domain and its intermodule docking domain. Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12432-12437. PubMed Central PMCID: PMC5098645.
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