Areas of Expertise
Enzyme structure and mechanism, Macromolecular X-ray crystallography, Enzymology, Molecular Biology, Metalloenzymes, Iron-sulfur clusters, Vitamin B12, S-adenosyl-L-methionine and adenosylcobalamin radical enzymes, Posttranslational modifying enzymes, Posttranscriptional modifying enzymes, Natural product biosynthesis
PhD, Biological Chemistry, University of Pennsylvania
We primarily use X-ray crystallography and biochemical techniques to study the structures and functions of important biological systems. Our research focuses on two main areas:
- Challenging chemistry in natural product biosynthesis. We are particularly interested in heterocycle formation within nonribosomal peptide synthetases and complex free-radical chemistry involved in natural product biosynthesis.
- Posttranslational or posttranscriptional modifying enzymes with implications in treating different diseases. Current work focuses on kinases and metallo-deacetylases.