Macoska Laboratory

at the University of Massachusetts Boston

Macoska Laboratory

Research in the Macoska Laboratory is currently focused on:

  1. Defining the mechanisms through which dysfunctional paracrine interactions between diverse cell types—epithelial, fibroblastic, endothelial, leukocytic—develop consequent to the aging process, and how these dysfunctional interactions contribute to the development of benign and malignant  disease;
  2. Elucidating the intracellular mechanisms through which growth factors, particularly CXC-type chemokines, secreted by aging stromal fibroblasts stimulate cellular proliferation and myofibroblast phenoconversion, and the association of these pathobiologies with organ dysfunction and malignancy; and
  3. Translating laboratory-based knowledge to the development of clinically efficacious therapeutics to slow or arrest the initiation or progression of benign and malignant diseases associated with inflammation and fibrosis.

Jill Macoska

See Jill Macoska's bio and CV. Read More